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Oleksii Skorokhod

Associate Professor

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Curriculum vitae

  • Curriculum Vitae (0.1 MB)

    • Research products

    All my research products

    Selected research products

    1. Perepelytsia I, Bozhok G, Berest V, Gallo V, Pizzi M, Sichevska L, Skorokhod O. Liposomal Encapsulation Reduces the Cytotoxic Effects of Gramicidin S in Monolayer and Spheroid Fibroblast Cultures. Antibiotics (Basel). 2026 Feb 6;15(2):177. doi: 10.3390/antibiotics15020177. PMID: 41750475; PMCID: PMC12937420.
    2. Gnatyuk O, Skorokhod O, Damin A, Chaika M, Naeimaeirouhani F, Pica L, Tomatis A, Smorygo A, Voitsitskyi T, Catucci G, Dovbeshko G, Gilardi G. Structural Impact of 4-Hydroxynonenal Modification on Human Cytochrome CYP4F11. ChemMedChem. 2026 Jan;21(2):e202500935. doi: 10.1002/cmdc.202500935. PMID: 41619286; PMCID: PMC12860540.
    3. Voloshchuk OM, Kopylchuk HP, Ursatyy MS, Kovalchuk KA, Skorokhod O. Alterations in Adenylate Nucleotide Metabolism and Associated Lipid Peroxidation and Protein Oxidative Damage in Rat Kidneys Under Combined Acetaminophen Toxicity and Protein Deficiency. Antioxidants (Basel). 2026 Jan 13;15(1):105. doi: 10.3390/antiox15010105. PMID: 41596163; PMCID: PMC12837607.
    4. Berest V, Sichevska L, Gorobchenko O, Perepelytsia I, Bozhok G, Skorokhod O. Lipid Composition of Nanocarriers Shapes Interactions of Cyclic Antimicrobial Peptide Gramicidin S with Their Membranes. Int J Mol Sci. 2025 Jul 19;26(14):6946. doi: 10.3390/ijms26146946. PMID: 40725193; PMCID: PMC12295741.
    5. Lasaviciute G, Tariq K, Sugathan A, Quin J, Polenkowski M, Bujila I, Skorokhod O, Troye-Blomberg M, Sverremark-Ekström E, Östlund Farrants AK. Malaria-derived hemozoin skews dendritic cell responses to bacterial infections by reducing interferon gene-transcription by SWI/SNF-NuRD. iScience. 2025 Jul 3;28(8):113046. doi: 10.1016/j.isci.2025.113046. PMID: 40717771; PMCID: PMC12296537.
    6. Skorokhod O, Barrera V, Valente E, Ulliers D, Uchida K, Schwarzer E. Malarial pigment induced lipoperoxidation, inhibited motility and decreased CCR2 and TNFR1/2 expression on human monocytes. Redox Experimental Medicine. 2025 Feb 1;1(aop).
    7. Vashchenko OV, Berest VP, Sviechnikova LV, Kutsevol NV, Kasian NA, Sofronov DS, Skorokhod O. Modifying Membranotropic Action of Antimicrobial Peptide Gramicidin S by Star-like Polyacrylamide and Lipid Composition of Nanocontainers. Int J Mol Sci. 2024 Aug 9;25(16):8691. doi: 10.3390/ijms25168691. PMID: 39201384; PMCID: PMC11354511.
    8. Lasaviciute G, Tariq K, Sugathan A, Quin J, Bujila I, Skorokhod O, Troye-Blomberg M, Sverremark-Ekström E, Farrants AK. Malaria-derived hemozoin alters chromatin remodelling and skews dendritic cell responses to subsequent bacterial infections. bioRxiv. 2024 Mar 19:2024-03.
    9. Schwarzer E, Skorokhod O. Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle. International Journal of Molecular Sciences. 2024; 25(11):6145. https://doi.org/10.3390/ijms25116145
    10. Skorokhod O, Vostokova E, Gilardi G. The role of P450 enzymes in malaria and other vector-borne infectious diseases. Biofactors. 2024 Jan-Feb;50(1):16-32. doi: 10.1002/biof.1996. Epub 2023 Aug 9. PMID: 37555735.
    11. Skorokhod O, Valente E, Mandili G, Ulliers D, Schwarzer E. Micromolar Dihydroartemisinin Concentrations Elicit Lipoperoxidation in Plasmodium falciparum-Infected Erythrocytes. Antioxidants (Basel). 2023 Jul 21;12(7):1468. doi: 10.3390/antiox12071468. PMID: 37508006; PMCID: PMC10376682.
    12. Skorokhod O, Triglione V, Barrera V, Di Nardo G, Valente E, Ulliers D, Schwarzer E, Gilardi G. Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression. Int J Mol Sci. 2023 Jun 16;24(12):10232. doi: 10.3390/ijms241210232. PMID: 37373382; PMCID: PMC10299294.
    13. Oberemok VV, Useinov RZ, Skorokhod OA, Gal’chinsky NV, Novikov IA, Makalish TP, Yatskova EV, Sharmagiy AK, Golovkin IO, Gninenko YI, Puzanova YV, Andreeva OA, Alieva EE, Eken E, Laikova KV, Plugatar YV. Oligonucleotide Insecticides for Green Agriculture: Regulatory Role of Contact DNA in Plant–Insect Interactions. International Journal of Molecular Sciences. 2022; 23(24):15681. https://doi.org/10.3390/ijms232415681
    14. Berneburg I, Peddibhotla S, Heimsch KC, Haeussler K, Maloney P, Gosalia P, Preuss J, Rahbari M, Skorokhod O, Valente E, Ulliers D, Simula LF, Buchholz K, Hedrick MP, Hershberger P, Chung TDY, Jackson MR, Schwarzer E, Rahlfs S, Bode L, Becker K, Pinkerton AB. An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0210921. doi: 10.1128/aac.02109-21. Epub 2022 Mar 10. PMID: 35266827; PMCID: PMC9017341.
    15. Skorokhod O, Barrera V, Mandili G, Costanza F, Valente E, Ulliers D, Schwarzer E. Malaria Pigment Hemozoin Impairs GM-CSF Receptor Expression and Function by 4-Hydroxynonenal. Antioxidants (Basel). 2021 Aug 6;10(8):1259. doi: 10.3390/antiox10081259. PMID: 34439507; PMCID: PMC8389202.
    16. Di Gregorio E, Ferrauto G, Schwarzer E, Gianolio E, Valente E, Ulliers D, Aime S, Skorokhod O. Relaxometric studies of erythrocyte suspensions infected by Plasmodium falciparum: a tool for staging infection and testing anti-malarial drugs. Magn Reson Med. 2020 Dec;84(6):3366-3378.
    17. Bergandi L, Skorokhod OA, La Grotta R, Schwarzer E, Nuzzi R. Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans. J Ophthalmol. 2019;2019:7231015. Published 2019 Oct 30. doi:10.1155/2019/7231015
    18. Loredana Bergandi, Oleksii A Skorokhod, Federica Franzone, Rosalba La Grotta, Evelin Schwarzer and Raffaele Nuzzi Induction of oxidative stress in human aqueous and vitreous humors by Nd:YAG laser posterior capsulotomy. Int J Ophthalmol 2018,11(7):1145-1151
    19. Gallo V, Skorokhod OA, Simula LF, Marrocco T, Tambini E, Schwarzer E, Marget P, Duc G, Arese P. No red blood cell damage and no hemolysis in G6PD-deficient subjects after ingestion of low vicine/convicine Vicia faba seeds. Blood. 2018; 131 (14): 1621-1625
    20. Oberemok VV, Laikova KV, Zaitsev AS, Shumskykh MN, Kasich IN, Gal'chinsky NV, Bekirova VV, Makarov VV, Agranovsky AA, Gushchin VA, Zubarev IV, Kubyshkin AV,Fomochkina II, Gorlov MV, Skorokhod OA. Molecular Alliance of Lymantria dispar Multiple Nucleopolyhedrovirus and a Short Unmodified Antisense Oligonucleotide of Its Anti-Apoptotic IAP-3 Gene: A Novel Approach for Gypsy Moth Control. Int J Mol Sci. 2017 Nov 17;18(11). pii: E2446. doi: 10.3390/ijms18112446. PubMed PMID: 29149051.
    21. Pantaleo A, Kesely KR, Pau MC, Tsamesidis I, Schwarzer E, Skorokhod OA, Chien HD, Ponzi M, Bertuccini L, Low PS, Turrini FM. Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress. Blood. 2017 Aug 24;130(8):1031-1040.
    22. Revelli A, Canosa S, Bergandi L, Skorokhod OA, Biasoni V, Carosso A, Bertagna A, Maule M, Aldieri E, D'Eufemia MD, Evangelista F, Colacurci N, Benedetto C. Oocyte polarized light microscopy, assay of specific follicular fluid metabolites, and gene expression in cumulus cells as different approaches to predict fertilization efficiency after ICSI. Reprod Biol Endocrinol. 2017 Jun 23;15(1):47.
    23. Oberemok VV, Laikova K, ,Zaitsev AS, Gushchin VA, Skorokhod OA, The RING for gypsy moth control: Topical application of fragment of its nuclear polyhedrosis virus anti-apoptosis gene as insecticide, Pesticide Biochemistry and Physiology (2016), http://dx.doi.org/10.1016/j.pestbp.2016.01.006
    24. Oberemok VV, Laikova K, ,Zaitsev AS, Gushchin VA, Skorokhod OA. Data for increase of Lymantria dispar male survival after topical application of single-stranded RING domain fragment of IAP-3 gene of its nuclear polyhedrosis virus, Data in Brief (2016), http://dx.doi.org/10.1016/j.dib.2016.03.007i
    25. Bujila I, Schwarzer E, Skorokhod O, Weidner JM, Troye-Blomberg M, Östlund Farrants AK. Malaria-derived hemozoin exerts early modulatory effects on the phenotype and maturation of human dendritic cells. Cell Microbiol. 2016 Mar;18(3):413-23. doi: 10.1111/cmi.12521. [Epub ahead of print] PubMed PMID: 26348250. IF=4.92
    26. Schwarzer E, Gallo V, Valente E, Ulliers D, Taglialatela-Scafati O, Arese P, Skorokhod OA. Preferential binding of 4-hydroxynonenal to lysine residues in specific parasite proteins in plakortin-treated Plasmodium falciparum-parasitized red blood cells. Data Brief. 2015 Nov 11;5:893-9.
    27. Skorokhod OA, Davalos-Schafler D, Gallo V, Valente E, Ulliers D, Notarpietro A, Mandili G, Novelli F, Persico M, Taglialatela-Scafati O, Arese P, Schwarzer E. Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex. Free Radic Biol Med. 2015 Oct 13;89:624-637.
    28. Schwarzer E, Arese P, Skorokhod OA. Role of the lipoperoxidation product 4-hydroxynonenal in the pathogenesis of severe malaria anemia and malaria immunodepression. Oxid Med Cell Longev. 2015;2015:638416. doi: 1155/2015/638416. IF=3.53
    29. Skorokhod OA, Barrera V, Heller R, Carta F, Turrini F, Arese P, Schwarzer E. Malarial pigment hemozoin impairs chemotactic motility and transendothelial migration of monocytes via 4-hydroxynonenal. Free Radic Biol Med. 2014 Oct;75:210-21
    30. Oberemok VV, Skorokhod OA. Single-stranded DNA fragments of insect-specific nuclear polyhedrosis virus act as selective DNA insecticides for gypsy moth control. Pestic Biochem Physiol. 2014 Jul;113C:1-7. doi:10.1016/j.pestbp.2014.05.005. Epub 2014 Jun 10. PubMed PMID: 25052520.
    31. Zhang G, Skorokhod OA, Khoo SK, Aguilar R, Wiertsema S, Nhabomba AJ, Marrocco T, McNamara-Smith M, Manaca MN, Barbosa A, Quintó L, Hayden CM, Goldblatt J, Guinovart C, Alonso PL, Dobaño C, Schwarzer E, Lesouëf PN. Plasma advanced oxidative protein products are associated with anti-oxidative stress pathway genes and malaria in a longitudinal cohort. Malar J. 2014 Apr 3;13(1):134.
    32. Ruth Aguilar, Tiziana Marrocco, Oleksii A Skorokhod, Arnoldo Barbosa, Augusto Nhabomba, Maria Nélia Manaca, Caterina Guinovart, Llorenç Quintó, Paolo Arese , Pedro L Alonso, Carlota Dobaño, Evelin Schwarzer. Blood oxidative stress markers and Plasmodium falciparum malaria in non-immune African children. British Journal of Haematology, 2014, 164(3):438-450
    33. Valentina Gallo, Oleksii A Skorokhod, Evelin Schwarzer, Paolo Arese. Simultaneous determination of phagocytosis of Plasmodium falciparum-parasitized and non-parasitized red blood cells by flow cytometry. Malaria Journal 2012,11:428 doi:10.1186/1475-2875-11-428
    34. Sophie Uyoga, Oleksii A. Skorokhod, Michael Opiyo, Emily N. Orori, Thomas N. Williams, Paolo Arese, Evelin Schwarzer. Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia. British Journal of Haematology, 2012, 157(1): 116-124
    35. Godfrin Y, Horand F, Franco R, Dufour E, Kosenko E, Bax BE, Banz A, Skorokhod OA, Lanao JM, Vitvitsky V, Sinauridze E, Bourgeaux V, Gunter KC. Meeting highlights: international seminar on the red blood cells as vehicles for drugs. Expert Opin Biol Ther. 2012; 12(1):127-133
    36. Barrera V, Skorokhod OA, Baci D, Gremo G, Arese P, Schwarzer E. Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action. Blood. 2011;117(21):5674-82
    37. Skorokhod OA, Caione L, Marrocco T, Migliardi G, Barrera V, Arese P, Piacibello W, Schwarzer E. Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal. Blood. 2010 Nov 18;116(20):4328-37.
    38. Schwarzer E, Skorokhod, V. Barrera, P. Arese, Hemozoin and the human monocyte-A brief review of their interactions. Parassitologia 2008 50: 143-145
    39. Skorokhod OA, Schwarzer E, Ceretto M, Arese P, Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes. Malar J. 2007 Jun 2;6(1):73.
    40. Skorokhod O, Kulikova EV, Galkina NM, Medvedev PV, Zybunova EE, Vitvitsky VM, Pivnik AV, Ataullakhanov FI. Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes. Haematologica. 2007 Apr;92(4):570-1.
    41. Skorokhod A, Schwarzer E, Gremo G, Arese P. HNE produced by the malaria parasite Plasmodium falciparum generates HNE-protein adducts and decreases erythrocyte deformability. Redox Rep. 2007;12(1):73-5.
    42. Skorokhod O, Schwarzer E, Grune T, Arese P. Role of 4-hydroxynonenal in the hemozoin-mediated inhibition of differentiation of human monocytes to dendritic cells induced by GM-CSF/IL-4. Biofactors. 2005; 24(1-4):283-9.
    43. Skorokhod OA, Alessio M, Mordmuller B, Arese P, Schwarzer E. Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect. J Immunol. 2004 Sep 15; 173(6): 4066-74.
    44. Skorokhod OA, Garmaeva TT, Vitvitsky VM, Isaev VG, Parovichnikova EN, Savchenko VG, Ataullakhanov FI. Pharmacokinetics of erythrocyte-bound daunorubicin in patients with acute leukaemia. Med Sci Monit. 2004 Mar 23;10(4):PI55-PI64
    45. Ayi, G. Giribaldi, A. Skorokhod, E. Schwarzer, P.T. Prendergast, P.Arese, “16alpha-Bromoepiandrosterone, an Antimalarial Analogue of the Hormone Dehydroepiandrosterone, Enhances Phagocytosis of Ring Stage Parasitized Erythrocytes: a Novel Mechanism for Antimalarial Activity”, Antimicrobial Agents and Chemotherapy, 2002, 46 (10): 3180-4
    46. Isaev VG, Garmaeva TTs, Skorokhod AA, Parovichnikova EN, Tyurina NG, Kucher RA, Vitvitsky VM, Ataullakhanov FI, Savchenko VG, “Immobilized forms of daunorubicin in patients with acute leukemia”, Ter Arkh 1999; 71(10):32-7
    47. Pivnik AV, Shtroiakovskii DL, Medvedev PV, Moiseeva TN, Shklovskii-Kordi NE, Skorokhod AA, “Liposomal daunorubicin (daunosom) in the treatment of recurrent acute promyelocytic leukemia”, Ter Arkh 1999; 71(7):24-7
    48. Skorokhod AA, Vitvitskii VM, Kul'man RA, Ataullakhanov FI, “Detrimental effects of Daunorubicin and Doxorubicin on human erythrocytes in vitro”, Vopr Onkol, 1999; 45(4): 374-9

     

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    Meccanismi patofisiologici legati alla perossidazione lipidica nella malaria. Ruolo del citocromo P450 CYP4F11 in immunosoppressione.

     

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